Urinary Myelin Basic Protein–like Material in Patients With Multiple Sclerosis During Interferon Beta-1b Treatment

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Urinary myelin basic protein-like material in patients with multiple sclerosis during interferon beta-1b treatment.

OBJECTIVES To determine levels of urinary myelin basic protein-like material (MBPLM) in patients with multiple sclerosis (MS) openly treated with interferon beta-1b and to correlate these with clinical changes. BACKGROUND Levels of urinary MBPLM correlate with the presence of the progressive phase of MS and with the disease burden detected on T2-weighted, cranial magnetic resonance imaging. M...

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Application of Interferon Beta-1b in Multiple Sclerosis

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BACKGROUND Although patients with multiple sclerosis (MS) are advised to stop interferon (IFN) beta-1a therapy before becoming pregnant, some patients become pregnant while on treatment. METHODS We examined individual patient data from eight clinical trials with IFNbeta-1a. RESULTS Of 3,361 women in the studies, 69 pregnancies were reported, of which 41 were patients receiving (or who had s...

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ژورنال

عنوان ژورنال: Archives of Neurology

سال: 1999

ISSN: 0003-9942

DOI: 10.1001/archneur.56.6.687